| Savoie | Derived from the Latin word sapaudia. |
| Savu | A Finnish name meaning wise. |
| Savyas | One who is very skillful. |
| Saw | A name meaning to perceive. |
| Scale | A name meaning to climb up. |
| Scathach | A legendary warrior woman. |
| Scheana | A name meaning God is kind. |
| Schwartz | A name meaning dark color. |
| Screech | A name meaning sharp sound. |
| Script | A name meaning written text. |
| Sebek | An ancient Egyptian god. |
| Securitas | The Roman goddess of security. |
| Sedna | Inuit goddess of the deep sea. |
| Seia | Roman goddess of sown seeds. |
| Sekh | Ancient Egyptian for power. |
| Sekhem | Egyptian term for life force. |
| Sekhmet | Egyptian goddess of war. |
| Selket | Egyptian goddess of healing. |
| Selkie | A mythical sealfolk creature. |
| Selyse | A name meaning noble or kind. |
| Seno | A name meaning gift of God. |
| Sentia | Derived from the Latin word for feeling. |
| Sentry | A soldier stationed to keep a guard. |
| Senua | Ancient name linked to a Celtic deity. |
| Seo | A Korean name meaning auspicious omen. |
| Septa | A term referring to a partition wall. |
| Septon | A religious leader in fantasy fiction. |
| Seram | Named after an island in Indonesia. |
| Serama | A small breed of ornamental chicken. |
| Sereia | The Portuguese word for a mermaid. |
| Serein | Fine rain falling from a clear sky. |
| Serenade | A musical performance for a lover. |
| Serket | Egyptian goddess of healing scorpions. |
| Server | A computer providing network services. |
| Servo | A device for precise motion control. |
| Seshat | Ancient Egyptian goddess of writing. |
| Setesh | Ancient Egyptian god of the desert. |
| Seti | Name meaning of the god of the desert. |
| Shemsu | A loyal follower or servant. |
| Sherbet | A sweet, refreshing drink. |